The first 10 years' experience of restorative proctocolectomy for ulcerative colitis.

Progress with the pouch--restorative proctocolectomy for ulcerative colitis.

proctocolectomy for ulcerative colitis

Between 1976 and 1985, 110 patients had restorative proctocolectomy or proctectomy for ulcerative colitis and 103 were foilowed up until death or February 1992. There was one postoperative and one late death related to surgery. The cumulative probability of pouch failure was 12% at five years: half of the failures occurred within one year. The commonest reasons were perianal/pelvic sepsis and p...

Complications and functional outcomes of restorative proctocolectomy for ulcerative colitis in the elderly

BACKGROUND Restorative proctocolectomy with ileopouch-anal anastomosis (IPAA) is the treatment of choice for intractable or complicated ulcerative colitis (UC). Debate exists concerning outcomes of IPAA in the elderly and literature data are scarce. We report our experience of IPAA in older population. METHODS We gathered data on a prospective database of patients undergoing IPAA for UC over ...

Elemental diet therapy for pouchitis following restorative proctocolectomy for ulcerative colitis.

I read with interest the article by McLaughlin et al., ‘Exclusive elemental diet impacts on the gastrointestinal microbiota and improves symptoms in patients with chronic pouchitis’.1 In their case series, 7 patients with pouchitis following restorative proctocolectomy for ulcerative colitis (UC) were treated with exclusive elemental diet therapy for 4 weeks. The median stool frequency signific...

Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis.

AIM To investigate matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pouch mucosa of pediatric onset ulcerative colitis (UC). METHODS In this cross-sectional study, 28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years (median) after proctocolectomy. Expression of MMPs-3, -7, -8, -9, -12 and -26 and TIMPs-1, -2 and -3 in samples was examined using imm...